Anesthetic 347

Name	2-Chloro-1,1,2-Trifluoroethyl Difluoromethyl Ether
Synonyms	C 347 Efrane Alyrane compound347 Compound 347 Anesthetic 347 anestheticcompoundno.347 Anesthetic Compound No. 347 2-Chloro-1,1,2-Trifluoroethyl Difluoromethyl Ether
CAS	13838-16-9
EINECS	237-553-4
InChIKey	JPGQOUSTVILISH-UHFFFAOYSA-N

Risk Codes	36 - Irritating to the eyes
Safety Description	S23 - Do not breathe vapour. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S39 - Wear eye / face protection.
UN IDs	UN 3334
RTECS	KN6800000
HS Code	2909191800
Hazard Note	Flammable/Toxic
Toxicity	LD50 oral in rat: 5450uL/kg

EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
pharmacological effects	It is easy to make ning very stable in chemical properties, with high efficiency and moderate intensity of general anesthesia; due to the small blood/gas partition coefficient, induction and recovery are faster. This product has a certain analgesic and muscle relaxant effect, and has a synergistic effect with non-depolarizing muscle relaxant. After the administration is stopped, the muscle relaxant effect rapidly disappears. This product inhibits the myocardium, reduces peripheral vascular resistance, and thus blood pressure drops; But does not increase the sensitivity of the myocardium to catecholamines. With other drugs can be used for controlled hypotension. This product significantly inhibits breathing, can reduce lung compliance, dilate the bronchi, less cause Cough and Laryngospasm; Inhibit gastrointestinal motility and gland secretion, but less Nausea, Vomit. Lower intraocular pressure, suitable for ophthalmic surgery. After inhalation, more than 80% of the product is exhaled from the lung in its original form, and only 2% ~ 5% is metabolized, which is mainly catalyzed by liver microsomal enzymes and becomes fluoride excreted with urine. The fat/gas partition coefficient is low and is prone to degradation away from the fat.
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)

Last Update：2024-04-10 22:29:15